Benzene is a chemical that is a colorless or light yellow liquid at room temperature. - Benzene has a ring of carbon atoms in its structure. It is now considered aromatic because it obeys Hückel's rule: 4n + 2 = number of π electrons in the hydrocarbon, where n must be an integer. Benzene is also classified as a known human carcinogen (category A) by the EPA and American Conference of Governmental Industrial Hygienists (ACGIH). An organic compound is classified as aromatic if it fits which of the following criteria? In the case of benzene… Benzene is classified as a Group 1 carcinogen. Introduction. 1. Benzene and its metabolites may cause leukemia via genotoxic effects on the pluripotent hematopoietic stem cells, resulting in chromosomal changes . The benzene molecular structure is made of six carbon atoms arranged in a ring with one atom of hydrogen attached to each carbon atom. Compounds containing benzene rings (see above) are aromatic compounds. Benzene. a. Other articles where Benzene ring is discussed: hydrocarbon: Aromatic hydrocarbons: …All compounds that contain a benzene ring possess special stability and are classified as benzenoid aromatic compounds. Benzene is classified as a known human carcinogen by various regulatory agencies worldwide. 1,3: Benzene causes acute myeloid leukaemia (acute non-lymphocytic leukaemia), and there is limited evidence that benzene may also cause acute and chronic lymphocytic leukaemia, non-Hodgkin's lymphoma and multiple myeloma. It is harmful to the eyes, skin, airway, nervous system, and lungs. Alternating Л and δ bonds The exposure circumstance entails exposures that are carcinogenic to humans. Under the proposed revised Carcinogen Risk Assessment Guidelines (U.S. EPA, 1996), benzene is characterized as a known human carcinogen for all routes of exposure based upon convincing … CY1400000. Benzene is classified as a flammable liquid and should be stored away from any potential source of ignition. It is highly flammable and has low water solubility. Originally, benzene was considered aromatic because of its smell: it has an "aromatic" odor. 1114 130. Consequently, benzene is classified as T, Cat 1 (H372) according to Regulation (EC) No 1272/2008 of the European Parliament. Individuals Formula. Classification according to EU Directives 67/548/EEC or 1999/45/EC Occupational exposure to benzene is linked to leukemia. 71-43-2 RTECS No. Benzene is a colourless liquid with a gasoline-like odour. The link between benzene and cancer has largely focused on leukemia and other cancers of blood cells. b. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. THE FACTS BENZENE Benzene is classified as Group 1 carcinogen by the IARC, meaning it is seen as a definite cause of cancer in humans. A number of studies and reviews have linked Benzene exposure to certain forms of leukemia. Planar structure. Benzene is classified as a human carcinogen … Certain other compounds lack a benzene ring yet satisfy the criterion of special stability and are classified as … Benzene is a colourless liquid with a characteristic odour and is primarily used in the production of polystyrene. Benzene is a component of man-made fragrances that are added cosmetics. Because of the flammability, toxicity, and volatility of benzene, transfers from one vessel to another are conducted in closed systems. Benzene exposure can cause chromosomal aberrations in animals and humans. Benzene. Benzene is known as an “aromatic hydrocarbon”. Benzene dissolves only slightly in water and will float on top of water. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Synonyms & Trade Names Benzol, Phenyl hydride CAS No. The Phenyl Group. Benzene evaporates into the air very quickly. Benzene is an organic chemical with the chemical formula C 6 H 6 and CAS number 71-43-2. Because benzene is a Category 1 carcinogen (i.e., a known or presumed human carcinogen), a mixture containing benzene at a concentration greater than or equal to 0.1% would be classified as a Category 1 carcinogen and require appropriate hazard information on the product’s label and SDS. It is classified by the International Agency for Research on Cancer as a Group 1 human carcinogen. Uses. Significantly increased risks of leukemia, chiefly acute myelogenous leukemia, have been reported in benzene-exposed workers in the chemical industry, shoemaking, … The main way people are exposed is by breathing in air containing benzene. Benzene is classified as a “known” human carcinogen (Category A) under the EPA Risk Assessment Guidelines of 1986. Benzene is shipped by rail tank cars, trucks, barges, and tankers. It is fragrant. Substances, mixtures, and exposure circumstances in this list have been classified as Group 1 by the International Agency for Research on Cancer (IARC): The agent (mixture) is carcinogenic to humans. Under the proposed revised Carcinogen Risk Assessment Guidelines (U.S. EPA, 1996), benzene is characterized as a known human carcinogen for all routes of exposure based upon convincing … It has a sweet odor and is highly flammable. In the United States, the Environmental Protection Agency (EPA), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), and National Institutes of Health (NIH) all classify benzene as either … To be classified as aromatic, a compound must have : Cyclic structure. It is classified as a hydrocarbon as it has only carbon and hydrogen atoms. This a different use of the word. Benzene is a highly toxic compound, and long-term exposure to benzene can cause anemia, leukemia, and other medical conditions [1]. Basis: Benzene is classified as a "known" human carcinogen (Category A) under the Risk Assessment Guidelines of 1986. Substantial quantities of epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute leukemia, bone marrow abnormalities and cardiovascular disease. Benzene is the simplest aromatic hydrocarbon and belongs to the group volatile organic compounds (VOC). Chemicals that are composed of only hydrogen and carbon are called hydrocarbons. Further, the relevant product Material c. It contains at least one C=C bond. - Benzene is a liquid at room temperature As mentioned previously, the phenyl group (Ph-R, C 6 H 5-R) can be formed by removing a hydrogen from benzene and attaching a substituent to where the hydrogen was removed.To this phenomenon, we can name compounds formed this way by applying this rule: (phenyl + substituent).For example, a … benzene is an unsaturated hydrocarbon. Benzene can cause blood cancers like leukemia. Chronic benzene exposure has also been associated with lung cancer in epidemiological studies. - Benzene contains only carbon and hydrogen. Leukemia is a malignant disease that affects the blood and bone marrow. Appropriate personal protective equipment practices and labeling, storage, and transportation procedures must be followed. Long-term exposure to benzene may increase the incidence of a specific type of leukemia (acute myelogenous leukemia) and may be associated with other forms of leukemia and lymphomas (cancers that develop from cells in the lymphatic system). The chemical properties of substituted benzenes are determined both by the aromatic groups and by the properties of the group … Aromatic compounds are compounds that resemble benzene in chemical behavior thus they tend to react by substitution rather than by addition and fulfill the aromaticity requirements. Benzene is considered to be unsaturated because it has double carbon-carbon covalent bonds. Workers may be harmed from exposure to benzene. which of the following is NOT a property of benzene? - Benzene undergoes the same reactions that other unsaturated hydrocarbons do. It is highly toxic and is a known carcinogen; exposure to it may cause leukemia. The assignment of a registration number does however not guarantee that the … Benzene is an aromatic hydrocarbon because it obeys Hückel's rule. Related Pages. DOT ID & Guide. Because of the distinctive smell of benzene (and related compounds), the benzene family is classified as “aromatic”; thus, the name, aromatic hydrocarbon. NOTE: NIOSH has classified this substance as a potential occupational carcinogen, according to specific NIOSH criteria. benzene is carcinogenic to humans. benzene leads to aplastic anemia, and may lead to leukemia after 6 months to 6 years of chronic exposure. Benzene is a well-known environmental contaminant that was classified as a human carcinogen (IARC Group 1) in 1974 , which was recently reconfirmed . Benzene evaporates quickly when exposed to the air and has a sweet smell. Benzene is classified as a carcinogen, which increases the risk of cancer and other illnesses, and is also a notorious cause of bone marrow failure. If there are other groups present on the benzene ring the compound is said to be a substituted benzene. Benzene is classified as “Carcinogenic to Humans” by the World Health Organization. Its vapor is heavier than air and may sink into low-lying areas. Basis: Benzene is classified as a "known" human carcinogen (Category A) under the Risk Assessment Guidelines of 1986. The level of exposure depends upon the dose, duration, and work being … Benzene (C6H6) is a highly flammable, colorless liquid that evaporates quickly into the air. The ICH has classified benzene as a Class 1 solvent with a limit of NMT 2 ppm [2], and people in pharma and pharma-related industries are very concerned about controlling and minimizing the levels of benzene … In modern usage, we use the term organic to describe a type of farming was intended to be healthier for humans. for Research on Cancer has classified benzene as : carcinogenic to humans (Group 1). Benzene is known to cause acute myeloid leukaemia/acute non-lymphocytic leukaemia and potentially other cancers in humans. Benzene derived products are well known to be pleasantly fragrant.For this reason, organic compounds containing benzene rings were classified as being "aromatic" (sweet smelling) amongst scientists in the early 19th century when a relation was established between benzene derived compounds and sweet/spicy … Benzene is used for production of other chemicals during manufacture of plastics, nylon, synthetic … It is cyclic. 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